Physiology· 2014Q1
Melatonin: Exceeding Expectations
- 599citations
- Q1SCImago
- 2014year
Short summary
Melatonin demonstrates both receptor-mediated (circadian rhythm, sleep, cancer inhibition) and potent receptor-independent antioxidant actions, protecting against oxidative stress in conditions like stroke and radiation.
AI-generated from the title and abstract; the full text is not read.
Key points
- Melatonin has both receptor-mediated and receptor-independent actions.
- Receptor-dependent functions include circadian rhythm, sleep, and cancer inhibition.
- Receptor-independent actions involve free radical detoxification.
- Melatonin protects against oxidative stress in conditions like stroke, heart attack, and radiation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.
The authors' abstract, as published at the source. Physiology, 2014 · DOI ↗
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Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience