Fluids and Barriers of the CNS· 2020Q1· Review
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
- 1,795citations
- Q1SCImago
- 2020year
Short summary
This review details the blood-brain barrier's (BBB) structure, function, and the critical role of its integrity in maintaining brain homeostasis, alongside discussing BBB disruption in neurological conditions and biomarkers for assessing its permeability.
AI-generated from the title and abstract; the full text is not read.
Key points
- The BBB's structural and functional integrity is vital for brain homeostasis.
- Shear stress plays a role in maintaining BBB integrity.
- BBB disruption is linked to various neurological and pathological conditions.
- Biomarkers exist to assess BBB permeability, each with advantages and disadvantages.
AI-generated from the title and abstract; the full text is not read.
Abstract
The blood-brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain's metabolic activity as well as neuronal function. Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment. The different cells and structures contributing to developing this barrier are summarized along with the different functions that BBB plays at the brain-blood interface. We also explained the role of shear stress in maintaining BBB integrity. Furthermore, we elaborated on the clinical aspects that correlate between BBB disruption and different neurological and pathological conditions. Finally, we discussed several biomarkers that can help to assess the BBB permeability and integrity in-vitro or in-vivo and briefly explain their advantages and disadvantages.
The authors' abstract, as published at the source. Fluids and Barriers of the CNS, 2020 · DOI ↗
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Field: Neurology (Neuroscience)
NeurologyNeuroscience