Physiological Reviews· 2013Q1· Review
Claudins and the Modulation of Tight Junction Permeability
- 1,452citations
- Q1SCImago
- 2013year
Short summary
Claudins, a family of tight junction proteins, form paracellular barriers and pores that control epithelial and endothelial permeability.
AI-generated from the title and abstract; the full text is not read.
Key points
- Claudins are the main structural and functional components of tight junctions.
- They form paracellular barriers and selective pores.
- Their expression dictates the permeability of epithelial and endothelial layers.
- Recent advances in understanding claudin structure and function are discussed.
AI-generated from the title and abstract; the full text is not read.
Abstract
Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions.
The authors' abstract, as published at the source. Physiological Reviews, 2013 · DOI ↗
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Field: Neurology (Neuroscience)
NeurologyNeuroscience