Journal of Drug Delivery Science and Technology· 2026Q2
pH-responsive alginate-hyaluronic acid microbeads produced via optimized electrospray method for oral ibuprofen delivery
- 1citations
- Q2SCImago
- 2026year
Short summary
Electrospraying alginate-hyaluronic acid (ALG-HA) and cross-linking with calcium chloride produced uniform, spherical microbeads (mean diameters 2456 ± 146 μm and 638 ± 170 μm) that showed pH-responsive ibuprofen release, with low release in simulated gastric fluid and increased release in simulated intestinal fluid.
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Key points
- Electrospraying produced uniform ALG-HA microbeads with narrow size distributions (PDI 0.0035-0.0706).
- Mean bead diameters were measured at 2456 ± 146 μm and 638 ± 170 μm.
- Ibuprofen release was low in simulated gastric fluid (SGF) and increased in simulated intestinal fluid (SIF).
- The microbeads demonstrated pH-responsive release behavior.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Encapsulating active compounds in alginate–hyaluronic acid (ALG–HA) microbeads provides a biocompatible, calcium-cross-linkable platform for oral nonsteroidal anti-inflammatory drug delivery with the potential to minimize gastric drug release and promote intestinal release. To address the challenge of achieving uniformly spherical beads with narrow size distributions, we used electrospraying to generate ALG–HA droplets and subsequently ionotropically cross-linked them using calcium chloride. Bead size and morphology were characterized, rheology of pre-gel polymer solutions was assessed, and ibuprofen encapsulation and release were evaluated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The process yielded spherical microbeads with a narrow size distribution and consistent morphology, exhibiting mean diameters of 2456 ± 146 μm and 638 ± 170 μm, with PDI values ranging from 0.0035 to 0.0706. Ibuprofen release remained low in SGF and increased in SIF, demonstrating pH-responsive release behaviour. Electrosprayed, calcium cross-linked ALG–HA microbeads therefore constitute a promising platform for the oral delivery of ibuprofen, with potential for minimizing gastric drug release and promoting intestinal release. To our knowledge, this is the first assessment of electrosprayed, calcium cross-linked ALG–HA microbeads for pH-responsive ibuprofen delivery.
The authors' abstract, as published at the source. Journal of Drug Delivery Science and Technology, 2026 · DOI ↗
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Field: Electrical and Electronic Engineering
Electrical and Electronic EngineeringEngineering