Molecules· 2016Q1· Review
Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- 478citations
- Q1SCImago
- 2016year
Short summary
Capsaicin activates TRPV1 channels, leading to transient receptor potential vanilloid 1 (TRPV1) desensitization and subsequent analgesia, with potential applications beyond pain in obesity, diabetes, and cardiovascular conditions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Capsaicin activates TRPV1 channels, initiating a process of desensitization that underlies its analgesic effects.
- The desensitization mechanism offers a pathway for neuronal modulation of pain.
- Clinical applications of capsaicin extend beyond pain to potential therapies for obesity, diabetes, and cardiovascular conditions.
- Emerging research suggests therapeutic potential for capsaicin in cancer, airway diseases, itch, and gastric/urological disorders.
AI-generated from the title and abstract; the full text is not read.
Abstract
In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
The authors' abstract, as published at the source. Molecules, 2016 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Sensory Systems
Sensory SystemsNeuroscience