Science· 2025Q1
A human pan-disease blood atlas of the circulating proteome
- 56citations
- Q1SCImago
- 2025year
Short summary
A pan-disease blood proteome atlas profiling 5,416 proteins across 59 diseases and healthy cohorts (n=8,262) reveals shared and distinct protein signatures associated with age, sex, BMI, and specific diseases.
AI-generated from the title and abstract; the full text is not read.
Key points
- A harmonized proteomics dataset profiles up to 5,416 proteins in 8,262 individuals across 59 diseases and healthy cohorts.
- Identified proteins associated with demographic factors: age, sex, and body mass index.
- Revealed disease-specific protein signatures, highlighting shared and distinct patterns across conditions.
- The dataset is available as an online resource for disease-specific protein profile exploration.
AI-generated from the title and abstract; the full text is not read.
Abstract
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.
The authors' abstract, as published at the source. Science, 2025 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Spectroscopy
SpectroscopyChemistry