Organic Letters· 2026Q1
Ligand Accelerated Palladium-Catalyzed C–H Arylation of Electron-Deficient Polyfluoroarenes with Aryl Bromides
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- 2026year
Short summary
A new palladium-catalyzed C–H arylation method efficiently couples electron-deficient polyfluoroarenes with aryl bromides using low catalyst (0.25 mol%) and ligand (0.275 mol%) loadings under mild conditions.
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Key points
- Developed a ligand-accelerated palladium-catalyzed C–H arylation for electron-deficient polyfluoroarenes.
- Reaction uses low catalyst (0.25 mol% Pd) and ligand (0.275 mol%) loadings under mild conditions.
- Achieves good to excellent yields for a broad range of fluorinated biaryl products.
- Demonstrates wide substrate scope, good functional group tolerance, and utility in synthesizing industrially relevant molecules.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract A ligand accelerated highly efficient palladium-catalyzed C–H arylation of electron-deficient polyfluoroarenes with aryl and heteroaryl bromides has been developed. The reaction proceeds efficiently under mild conditions with low catalyst loading (0.25 mol % Pd) and ligand loading (0.275 mol %), affording a broad range of fluorinated biaryl products in good to excellent yields. The methodology exhibits a wide substrate scope and good functional group tolerance. Its synthetic utility is demonstrated through the concise synthesis of several industrially relevant molecules, highlighting the practicality, efficiency, and scalability of the catalytic system.
The authors' abstract, as published at the source. Organic Letters, 2026 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry