Angewandte Chemie International Edition· 2012Q1· Review
Palladium‐Catalyzed Cross‐Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize
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- Q1SCImago
- 2012year
Short summary
This review traces the historical origins and development of palladium-catalyzed cross-coupling reactions, which revolutionized C-C bond construction and earned Heck, Negishi, and Suzuki the 2010 Nobel Prize in Chemistry.
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Key points
- Palladium-catalyzed cross-coupling reactions enable practical C-C bond construction.
- Heck, Negishi, and Suzuki were awarded the 2010 Nobel Prize for their contributions.
- These methods have irreversibly changed organic synthesis strategies.
- The review outlines the historical development from seminal discoveries to modern applications.
AI-generated from the title and abstract; the full text is not read.
Abstract
In 2010, Richard Heck, Ei-ichi Negishi, and Akira Suzuki joined the prestigious circle of Nobel Laureate chemists for their roles in discovering and developing highly practical methodologies for C-C bond construction. From their original contributions in the early 1970s the landscape of the strategies and methods of organic synthesis irreversibly changed for the modern chemist, both in academia and in industry. In this Review, we attempt to trace the historical origin of these powerful reactions, and outline the developments from the seminal discoveries leading to their eminent position as appreciated and applied today.
The authors' abstract, as published at the source. Angewandte Chemie International Edition, 2012 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry