Chemical Reviews· 2016Q1· Review
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
- 2,905citations
- Q1SCImago
- 2016year
Short summary
Palladium-catalyzed C-N cross-coupling reactions are now essential for synthesizing anilines and derivatives, driven by the development of versatile catalysts and user-friendly conditions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Pd-catalyzed C-N cross-coupling reactions are vital for aniline synthesis.
- Catalyst development has enabled user-friendly reaction conditions.
- Applications span heterocycles, medicinal chemistry, materials science, and more.
- The review covers literature from 2008 to the present.
AI-generated from the title and abstract; the full text is not read.
Abstract
Pd-catalyzed cross-coupling reactions that form C-N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C-N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.
The authors' abstract, as published at the source. Chemical Reviews, 2016 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry