Journal of Virology· 2026Q1
H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves
- 9citations
- Q1SCImago
- 2026year
Short summary
An H5 mRNA-LNP vaccine induced robust antibody and CD8+ T cell responses and protected Holstein calves against H5N1 infection.
AI-generated from the title and abstract; the full text is not read.
Key points
- H5 mRNA-LNP vaccine induced robust antibody responses in Holstein calves.
- The vaccine also elicited a significant CD8+ T cell-mediated immune response.
- Vaccinated calves were protected against clade 2.3.4.4b H5N1 infection.
- The study addresses the need for intervention strategies against H5N1 in cattle.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 circulated widely in lactating dairy cows in the United States following the initial detection in 2024. Due to the critical need for intervention strategies for this outbreak, we evaluated antibody and cellular immune responses of a clade 2.3.4.4b H5 mRNA-LNP vaccine in calves. We found that the H5 mRNA-LNP vaccine induced a robust antibody and CD8 + T cell-mediated immune response and conferred protection against clade 2.3.4.4b H5N1 infection. IMPORTANCE It is important to develop vaccines that limit clade 2.3.4.4b H5N1 infection in cattle. In this study, we found that a new H5 mRNA-lipid nanoparticle vaccine is immunogenic when delivered intramuscularly to male Holstein calves.
The authors' abstract, as published at the source. Journal of Virology, 2026 · DOI ↗
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Field: Epidemiology
EpidemiologyMedicine