Cellular Physiology and Biochemistry· 2015Q3· Review
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
- 16,339citations
- Q3SCImago
- 2015year
Short summary
Autophagy, a crucial cellular degradation process, is increasingly implicated in the pathology of various ocular diseases.
AI-generated from the title and abstract; the full text is not read.
Key points
- Autophagy is a fundamental intracellular process for protein degradation.
- Dysfunctional autophagy is linked to the pathology of numerous ocular diseases.
- Autophagy-related proteins are constitutively expressed in ocular tissues.
- Pharmacological modulation of autophagy offers potential therapeutic strategies for eye diseases.
AI-generated from the title and abstract; the full text is not read.
Abstract
Autophagy is an important intracellular degradative process that delivers cytoplasmic proteins to lysosome for degradation. Dysfunction of autophagy is implicated in several human diseases, such as neurodegenerative diseases, infectious diseases, and cancers. Autophagy-related proteins are constitutively expressed in the eye. Increasing studies have revealed that abnormal autophagy is an important pathological feature of several ocular diseases. Pharmacological manipulation of autophagy may provide an alternative therapeutic target for some ocular diseases. In this manuscript, we reviewed the relevant progress about the role of autophagy in the pathogenesis of ocular diseases.
The authors' abstract, as published at the source. Cellular Physiology and Biochemistry, 2015 · DOI ↗
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Field: Epidemiology
EpidemiologyMedicine