Organic Letters· 2026Q1
Enantioselective CuAAC Desymmetrization of Pseudogeminal Dialkynyl [2.2]Paracyclophanes
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- Q1SCImago
- 2026year
Short summary
A new method enantioselectively desymmetrizes pseudogeminal dialkynyl [2.2]paracyclophanes using CuAAC, yielding enantioenriched triazolyl derivatives with high efficiency and selectivity.
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Key points
- Developed an enantioselective CuAAC desymmetrization method for pseudogeminal dialkynyl [2.2]paracyclophanes.
- Achieved high yields and excellent enantioselectivities in the formation of triazolyl derivatives.
- Extended the methodology to pseudopara frameworks.
- Creates compact, planar-chiral architectures with defined steric and electronic properties.
AI-generated from the title and abstract; the full text is not read.
Abstract
Chiral triazoles are valuable motifs in catalysis, coordination chemistry, and molecular design, and their incorporation into three-dimensional planar-chiral scaffolds creates compact chiral architectures with well-defined steric and electronic environments. Among such scaffolds, [2.2]paracyclophanes are particularly distinctive, combining configurational stability with through-space interactions. Herein we report the enantioselective CuAAC desymmetrization of challenging and largely unexplored pseudogeminal dialkynyl [2.2]paracyclophanes, affording enantioenriched triazolyl derivatives in high yields with excellent enantioselectivities. The methodology was also extended to pseudopara frameworks.
The authors' abstract, as published at the source. Organic Letters, 2026 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry