iScience· 2026Q1· Review
Targeting TRP channels in hearing loss from mechanisms to otoprotection
- 0citations
- Q1SCImago
- 2026year
Short summary
This review synthesizes the role of Transient Receptor Potential (TRP) channels in hearing loss, detailing their spatiotemporal expression, involvement in hair cell mechanoelectrical transduction, and dual regulatory mechanisms, while highlighting emerging otoprotective drug candidates.
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Key points
- TRP channels are crucial in auditory physiology and pathology, influencing cochlear electrophysiology, ionic homeostasis, neurotransmitter release, and injury responses.
- The review details the spatiotemporal expression of TRP channels in the inner ear and the research progress on hair cell mechanoelectrical transduction (MET) channels.
- Emerging TRP-targeting otoprotective drug candidates are compiled, alongside an analysis of their dual regulatory mechanisms.
- Limitations include restricted preclinical models, scarce otoprotective drugs, and limited target diversity among existing agents.
AI-generated from the title and abstract; the full text is not read.
Abstract
Hearing loss, a highly prevalent global disease with complex pathogenic mechanisms, poses significant challenges due to limited treatment options and secondary complications. Recent research highlights the crucial roles of transient receptor potential (TRP) channels in auditory physiology and pathology, including cochlear electrophysiology, endolymph ionic homeostasis, neurotransmitter release, inflammation, and sensorineural injury responses. Although previous reviews synthesized TRP-mediated pathological mechanisms in hearing loss, clinical translation and otoprotective drug discovery remain underexplored. This review characterizes inner ear TRP spatiotemporal expression, traces the hair cell mechanoelectrical transduction (MET) channel research trajectory, details their dual regulatory mechanisms, and compiles emerging TRP-targeting otoprotective candidates. It further highlights limitations including restricted preclinical models, scarce otoprotective drugs, and limited target diversity among existing agents. Finally, it proposes new research directions for future basic and clinical studies on TRP channels and auditory function.
The authors' abstract, as published at the source. iScience, 2026 · DOI ↗
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Field: Sensory Systems
Sensory SystemsNeuroscience