PLoS Biology· 2026Q1
Alzheimer’s disease research must connect vascular molecular phenotypes with physiology
- 1citations
- Q1SCImago
- 2026year
Short summary
Alzheimer's disease research must integrate molecular vascular findings with physiological outcomes to prove causality.
AI-generated from the title and abstract; the full text is not read.
Key points
- Molecular profiling has identified vascular alterations in Alzheimer's disease.
- A causal role for these vascular changes in AD pathology is not yet proven.
- Longitudinal studies are needed to link molecular/structural changes to physiological functions.
- Key physiological functions to investigate include vascular mechanics, hemodynamics, and tissue perfusion.
AI-generated from the title and abstract; the full text is not read.
Abstract
Molecular profiling studies have mapped vascular alterations in Alzheimer's disease, but have not proven a role for them in pathology. Longitudinal studies are needed to link molecular and structural changes to vascular mechanics, hemodynamics, and tissue perfusion.
The authors' abstract, as published at the source. PLoS Biology, 2026 · DOI ↗
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Field: Physiology
PhysiologyMedicine