Organic Letters· 2026Q1
Total Synthesis of Bromophycoic Acid E
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- 2026year
Short summary
A novel asymmetric total synthesis of bromophycoic acid E, a halogenated meroterpenoid, is reported, establishing its absolute configuration and confirming its antimicrobial activity.
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Key points
- First asymmetric total synthesis of bromophycoic acid E completed.
- Acid-mediated intramolecular phenol cyclization used to construct the tetracyclic core.
- Radical deoxy bromination employed as a key synthetic step.
- Synthesis confirmed the antimicrobial activity of bromophycoic acid E.
- Absolute configuration of the natural product was determined.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract An asymmetric total synthesis of bromophycoic acid E, which belongs to the class of halogenated meroterpenoid natural products, is presented herein. The key steps in the synthesis are an acid-mediated intramolecular phenol cyclization for the construction of the tetracyclic core and a radical deoxy bromination. This synthesis revealed the absolute configuration of the natural product, confirmed its antimicrobial activity, and laid the groundwork for future structure–activity relationship studies.
The authors' abstract, as published at the source. Organic Letters, 2026 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry