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Organic Process Research & Development· 2026Q1

Synthesis of N -Linked Amino-Hexyl Fluorotryptophan for Enlicitide, Part 1: Route Scouting

Jeffrey T. Kuethe, Byron K. Peters, Keywan A. Johnson, Kai‐Jiong Xiao et al.

Short summary

A protecting-group-free synthesis of N-linked amino-hexylfluorotryptophan, a key building block for enlicitide decanoate, was developed using the Delepine reaction for alkylating agent preparation and direct alkylation of unprotected fluorotryptophan.

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Field: Organic Chemistry

Organic ChemistryChemistry