Organic Process Research & Development· 2026Q1
Synthesis of N -Linked Amino-Hexyl Fluorotryptophan for Enlicitide, Part 1: Route Scouting
- 1citations
- Q1SCImago
- 2026year
Short summary
A protecting-group-free synthesis of N-linked amino-hexylfluorotryptophan, a key building block for enlicitide decanoate, was developed using the Delepine reaction for alkylating agent preparation and direct alkylation of unprotected fluorotryptophan.
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Key points
- Developed a protecting-group-free synthesis for N-linked amino-hexylfluorotryptophan.
- Utilized the Delepine reaction to prepare the required alkylating agent.
- Achieved direct alkylation of unprotected fluorotryptophan.
- The synthesis is described as efficient and scalable for manufacturing enlicitide decanoate.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract One of the building blocks in the manufacture of the northern macrocycle of enlicitide decanoate is N-linked amino-hexylfluorotryptophan 1. An efficient, scalable, and protecting-group-free synthesis of this key building block is described. Hallmarks of the synthesis include the use of the Delépine reaction to prepare the required alkylating agent and the alkylation of unprotected fluorotryptophan.
The authors' abstract, as published at the source. Organic Process Research & Development, 2026 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry