PubMed· 2026
DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance
- 1,341citations
- 2026year
Short summary
A new theoretical framework, DQIS (Distributed Quorum-Based Independent Immune Surveillance), is proposed for achieving Byzantine fault tolerance in multi-channel immune surveillance systems.
AI-generated from the title and abstract; the full text is not read.
Key points
- Introduces DQIS, a theoretical framework for Byzantine fault tolerance.
- Focuses on multi-channel immune surveillance systems.
- Employs distributed quorum-based independent mechanisms.
- Aims to enhance reliability and security against failures or malicious actors.
AI-generated from the title and abstract; the full text is not read.
Abstract
A mathematic model has been developed relating the drug sensitivity of a tumor to its own spontaneous mutation rate towards phenotypic drug resistance. The proportion as well as the absolute numbers of resistant cells will increase with time and the fraction of resistant cells within tumor colonies of the same size with vary depending on whether mutation occurs as an early or late event. Analysis of the model indicates that the probability of the appearance of a resistant phenotype increases with the mutation rate. Furthermore, for any population of tumors with a non-zero mutation rate the likelihood of there being at least one resistant cell will go from a condition of low to high probability over a very short interval in the tumor's biologic history.
The authors' abstract, as published at the source. PubMed, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Modeling and Simulation
Modeling and SimulationMathematics