The Journal of Organic Chemistry· 2025Q2
Semiheterogeneous Intrinsic FeTiO3-Photoredox/Ph3N Dual-Catalyzed Fluoroalkylation of N-Heteroarenes with Alkenes and RfSO2Cl
- 36citations
- Q2SCImago
- 2025year
Short summary
A new semiheterogeneous method uses intrinsic FeTiO3 as a photocatalyst and Ph3N as a redox mediator to fluoroalkylate N-heteroarenes with alkenes and RfSO2Cl, achieving high yields and functional-group tolerance without sacrificial reagents.
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Key points
- Developed a semiheterogeneous dual-catalyzed system for fluoroalkylation of N-heteroarenes.
- Utilizes intrinsic FeTiO3 as a semiconductor photocatalyst and Ph3N as a redox mediator.
- Achieves high yields and excellent functional-group tolerance.
- Avoids the use of stoichiometric redox reagents or sacrificial electron donors/acceptors.
AI-generated from the title and abstract; the full text is not read.
Abstract
Herein, we report the sustainable semiheterogeneous synthesis of various fluoroalkylated N -heteroarenes using natural intrinsic iron(II) titanium oxide (FeTiO 3 ) as a semiconductor photocatalyst and Ph 3 N as a redox mediator. This synergistic system combines photogenerated electron-mediated fluoroalkyl sulfonyl chloride (R f SO 2 Cl) reduction with photogenerated hole-induced oxidative dehydrogenation aromatization, enabling high-yielding transformations with excellent functional-group tolerance while avoiding stoichiometric redox reagents or sacrificial electron donors/acceptors.
The authors' abstract, as published at the source. The Journal of Organic Chemistry, 2025 · DOI ↗
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