Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke

Short summary

Stroke triggers persistent microglial activation, leading to cholesterol buildup and metabolic changes that fuel chronic inflammation and hinder brain repair. Targeting microglial cholesterol overload with CYP46A1 activation improved white matter repair and functional recovery in male mice.

AI-generated from the title and abstract; the full text is not read.