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Science· 2016Q1

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Soyon Hong, Victoria F. Beja-Glasser, Bianca M. Nfonoyim, Arnaud Frouin et al.

Short summary

In Alzheimer's disease models, complement protein C1q and microglia drive early synapse loss before plaque formation, a process previously thought to occur later and be driven by neuroinflammation.

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Field: Neurology (Neuroscience)

NeurologyNeuroscience