The Journal of Organic Chemistry· 2025Q2
Synergistic Photocatalysis of Acridinium Salts and Pyridine N -Oxides for α-Aminoalkylation with N -Methylsulfonamides
- 85citations
- Q2SCImago
- 2025year
Short summary
A new photocatalytic method uses acridinium salts and pyridine N-oxides to achieve α-aminoalkylation of olefins with N-methylsulfonamides under mild conditions.
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Key points
- Synergistic photocatalysis using acridinium salts and pyridine N-oxides enables α-aminoalkylation.
- N-methylsulfonamides act as α-aminoalkylating reagents for olefins.
- The reaction proceeds under mild conditions with excellent atom economy and good site selectivity.
- The method is applicable to a broad range of substrates, including complex drug fragments.
AI-generated from the title and abstract; the full text is not read.
Abstract
This study presents a synergistic photocatalytic method using acridinium salts and pyridine N -oxides for the Giese reaction between N -methylsulfonamides and olefins, which utilizes N -methylsulfonamides as α-aminoalkylating reagents. Notable features of this approach include mild reaction conditions, excellent atom economy, good site selectivity, a broad substrate scope, and the ability to enable postmodification of complex drug fragments.
The authors' abstract, as published at the source. The Journal of Organic Chemistry, 2025 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry