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ACS Catalysis· 2026Q1

Enantioconvergent Assembly of Chiral Difluoromethyl Stereocenters by Nickel-Catalyzed Reductive Cross-Coupling

Zhiheng Li, Bo-heng Zhu, Lijun Tang, Xiao-Kang Dai et al.

Short summary

A nickel-catalyzed method creates chiral difluoromethyl-containing molecules with high enantioselectivity using a novel difluoromethyl alkyl triflate reagent.

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Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics