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Epigenetics· 2026Q1

A breast tissue-specific epigenetic clock provides accurate chronological age predictions and reveals de-correlation of age and DNA methylation in tumor-adjacent and tumor samples

Leonardo D. Garma, Sònia Pernas, Bartomeu Fullana, Andrea Vethencourt et al.

Short summary

A new Breast Tissue-specific Epigenetic Clock (BTEC) predicts chronological age in breast tissue with high accuracy (r=0.88, MAE=3.27 years), significantly outperforming pan-tissue models.

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Molecular BiologyBiochemistry, Genetics and Molecular Biology