Single‐cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti‐SSA antibodies and aberrant B cell populations

Short summary

Single-cell RNA sequencing of 1.5 million peripheral blood cells from 333 participants identified two distinct immunological subtypes of Sjögren's disease (SjD). SSA-positive SjD is characterized by a dominant IFN-I signature and altered transitional B cells, while SSA-negative SjD shows minimal differences from controls.

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