Analytical Chemistry· 2026Q1

Stoichiometry-Dependent Specificity in Biotin Enrichment: A Benchmarking Framework for Proximity-Labeling Proteomics

Christopher Arpad Zala, María Cristina Trueba Sánchez, Jelle van den Bor, Tijmen Willemsens et al.

1citations
Q1SCImago
2026year

Short summary

A new benchmarking framework reveals that biotin enrichment specificity in proximity labeling proteomics is highly dependent on biotin stoichiometry, with higher biotinylation levels yielding greater specificity and lower levels increasing non-specific background.

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Cell BiologyBiochemistry, Genetics and Molecular Biology