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Biomedicine & Pharmacotherapy· 2026Q1

Biomimetic recombinant humanized type III collagen peptide-RGD loaded alginate hydrogels enhance proliferation of mesenchymal-lineage cells via Integrin α5β1 activation

Lakshmi Jeevithan, Artiom Lijnev, José Eduardo Maté Sánchez de Val, Wenhui Wu et al.

Short summary

Alginate hydrogels loaded with both RGD and a recombinant humanized type III collagen peptide (CPR-HG) significantly enhanced proliferation and integrin α5β1 activation in mesenchymal stem cells (MSCs), human osteoblast-like cells (hFOB), and fibroblasts (FB), with superior performance compared to single-peptide hydrogels.

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Field: Immunology and Allergy

Immunology and AllergyMedicine