Cell Discovery· 2026Q1

The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis

Liang Guo, Baoying Huang, Hanzhi Yu, Yi Xu et al.

0citations
Q1SCImago
2026year

Short summary

The SARS-CoV-2 accessory protein ORF3a hijacks the ER chloride channel CLCC1, disrupting ER homeostasis and promoting viral pathogenesis, but CLCC1 acts as a host restriction factor by sequestering ORF3a.

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Cell BiologyBiochemistry, Genetics and Molecular Biology