Chemical Society Reviews· 2012Q1· Review
C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation
- 2,299citations
- Q1SCImago
- 2012year
Short summary
Rhodium(III) catalysis enables direct oxidative C-H activation to form C-C, C-N, and C-O bonds, offering a step-economic route to complex molecules from simple precursors.
AI-generated from the title and abstract; the full text is not read.
Key points
- Rhodium(III) catalysis facilitates direct oxidative C-H functionalization.
- Key bond formations include C-C, C-N, and C-O.
- Arene substrates with N/O directing groups are coupled with alkenes and alkynes.
- The method is step-economic, converting readily available materials into value-added molecules.
- Mechanisms are proposed, and comparisons with Pd(II) catalysis are discussed.
AI-generated from the title and abstract; the full text is not read.
Abstract
Rhodium(III)-catalyzed direct functionalization of C-H bonds under oxidative conditions leading to C-C, C-N, and C-O bond formation is reviewed. Various arene substrates bearing nitrogen and oxygen directing groups are covered in their coupling with unsaturated partners such as alkenes and alkynes. The facile construction of C-E (E = C, N, S, or O) bonds makes Rh(III) catalysis an attractive step-economic approach to value-added molecules from readily available starting materials. Comparisons and contrasts between rhodium(III) and palladium(II)-catalyzed oxidative coupling are made. The remarkable diversity of structures accessible is demonstrated with various recent examples, with a proposed mechanism for each transformation being briefly summarized (critical review, 138 references).
The authors' abstract, as published at the source. Chemical Society Reviews, 2012 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry