Current Topics in Medicinal Chemistry· 2016Q3· Review
Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry
- 1,971citations
- Q3SCImago
- 2016year
Short summary
Sulfur-containing functional groups are present in 362 FDA-approved drugs, with sulfonamides, thioethers, sulfones, and penicillin being the most common scaffolds.
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Key points
- Sulfur is a key heteroatom in drug design, found in 362 FDA-approved drugs.
- Common sulfur-containing scaffolds include sulfonamides, thioethers, sulfones, and penicillin.
- These scaffolds have been extensively studied for both their synthesis and therapeutic applications.
- Recent advances in the synthesis of these core sulfur-containing structures are presented.
AI-generated from the title and abstract; the full text is not read.
Abstract
The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of pharmaceuticals and natural products. For centuries, sulfur continues to maintain its status as the dominating heteroatom integrated into a set of 362 sulfur-containing FDA approved drugs (besides oxygen or nitrogen) through the present. Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades. In this review, these four moieties in pharmaceuticals and recent advances in the synthesis of the corresponding core scaffolds are presented.
The authors' abstract, as published at the source. Current Topics in Medicinal Chemistry, 2016 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry