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Angewandte Chemie International Edition· 2014Q1

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

Jiajia Dong, Larissa B. Krasnova, M. G. Finn, K. Barry Sharpless

Short summary

Sulfur(VI) fluorides (R-SO2-F and SO2F2) enable controlled S-F bond substitution for S-O bond formation, overcoming the reductive collapse issues of traditional S(VI) chlorides, with applications in small molecules, polymers, and biomolecules.

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Field: Organic Chemistry

Organic ChemistryChemistry