Angewandte Chemie International Edition· 2013Q1· Review
The Cross‐Dehydrogenative Coupling of CH Bonds: A Versatile Strategy for CC Bond Formations
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- Q1SCImago
- 2013year
Short summary
Cross-dehydrogenative coupling (CDC) enables direct C-C bond formation by activating two C-H bonds under oxidative conditions, offering a waste-minimized alternative to traditional methods requiring pre-functionalized starting materials.
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Key points
- CDC directly connects two C-H bonds under oxidative conditions.
- Reactive intermediates are generated in situ.
- CDC offers waste-minimized synthetic routes compared to classic coupling.
- This strategy avoids the use of pre-functionalized starting materials.
AI-generated from the title and abstract; the full text is not read.
Abstract
Over the last decade, substantial research has led to the introduction of an impressive number of efficient procedures which allow the selective construction of CC bonds by directly connecting two different CH bonds under oxidative conditions. Common to these methodologies is the generation of the reactive intermediates in situ by activation of both CH bonds. This strategy was introduced by the group of Li as cross-dehydrogenative coupling (CDC) and discloses waste-minimized synthetic alternatives to classic coupling procedures which rely on the use of prefunctionalized starting materials. This Review highlights the recent progress in the field of cross-dehydrogenative C sp 3C formations and provides a comprehensive overview on existing procedures and employed methodologies.
The authors' abstract, as published at the source. Angewandte Chemie International Edition, 2013 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry