Chemical Reviews· 2016Q1· Review
Advances in Synthetic Applications of Hypervalent Iodine Compounds
- 1,818citations
- Q1SCImago
- 2016year
Short summary
Hypervalent iodine compounds offer an environmentally sustainable alternative to heavy metal catalysts, enabling selective oxidations, halogenations, C-C bond formations, and more in organic synthesis.
AI-generated from the title and abstract; the full text is not read.
Key points
- Hypervalent iodine compounds are effective, environmentally sustainable alternatives to heavy metal catalysts in organic synthesis.
- They are employed in diverse reactions such as halogenation, oxidation, rearrangement, amination, and C-C bond formation.
- Recent progress includes the development of catalytic systems, recyclable reagents, and enantioselective reactions using chiral hypervalent iodine compounds.
- The review aims to promote the adoption of these compounds as greener synthetic tools.
AI-generated from the title and abstract; the full text is not read.
Abstract
The preparation, structure, and chemistry of hypervalent iodine compounds are reviewed with emphasis on their synthetic application. Compounds of iodine possess reactivity similar to that of transition metals, but have the advantage of environmental sustainability and efficient utilization of natural resources. These compounds are widely used in organic synthesis as selective oxidants and environmentally friendly reagents. Synthetic uses of hypervalent iodine reagents in halogenation reactions, various oxidations, rearrangements, aminations, C-C bond-forming reactions, and transition metal-catalyzed reactions are summarized and discussed. Recent discovery of hypervalent catalytic systems and recyclable reagents, and the development of new enantioselective reactions using chiral hypervalent iodine compounds represent a particularly important achievement in the field of hypervalent iodine chemistry. One of the goals of this Review is to attract the attention of the scientific community as to the benefits of using hypervalent iodine compounds as an environmentally sustainable alternative to heavy metals.
The authors' abstract, as published at the source. Chemical Reviews, 2016 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry