Molecules· 2020Q1· Review
A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications
- 1,654citations
- Q1SCImago
- 2020year
Short summary
Nitrogen-containing heterocycles are crucial in drug discovery, with over 75% of FDA-approved drugs featuring these structures.
AI-generated from the title and abstract; the full text is not read.
Key points
- Over 75% of FDA-approved drugs are nitrogen-containing heterocyclic moieties.
- New nitrogen-based heterocycles with significant physiological properties are continuously being designed.
- This review covers advances in novel nitrogen-containing heterocycles and their biological activities from 2019 to early 2020.
- Trends in using nitrogen-based moieties for drug design are highlighted.
AI-generated from the title and abstract; the full text is not read.
Abstract
The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.
The authors' abstract, as published at the source. Molecules, 2020 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry