Chemistry of Materials· 2013Q1· Review
The Thiol-Michael Addition Click Reaction: A Powerful and Widely Used Tool in Materials Chemistry
- 1,563citations
- Q1SCImago
- 2013year
Short summary
The thiol-Michael addition reaction is a versatile "click" chemistry tool enabling efficient, "green" synthesis and modification across applications from small molecules to in situ polymer modifications and surface functionalization.
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Key points
- The thiol-Michael addition reaction is a modular "click" reaction with high efficiency and "green" characteristics.
- Applications span small molecule synthesis, in situ polymer modifications in biological systems, and surface functionalization.
- Research has focused on understanding reaction mechanisms and modifying molecular structures for improved monomers.
- Recent developments over the past decade are emphasized in materials science applications.
AI-generated from the title and abstract; the full text is not read.
Abstract
The key attribute of the thiol-Michael addition reaction that makes it a prized tool in materials science is its modular “click” nature, which allows for the implementation of this highly efficient, “green” reaction in applications that vary from small molecule synthesis to in situ polymer modifications in biological systems to the surface functionalization of material coatings. Over the past few decades, interest in the thiol-Michael addition reaction has increased dramatically, as is evidenced by the number of studies that have been dedicated to elucidating different aspects of the reaction that range from an in-depth analysis aimed at understanding the mechanistic pathways of the reaction to synthetic studies that have examined modifying molecular structures with the aim of yielding highly efficient thiol-Michael reaction monomers. This review examines the reaction mechanisms, the substrates and catalysts used in the reaction, and the subsequent implementation of the thiol-Michael reaction in materials science over the years, with particular emphasis on the recent developments in the arena over the past decade.
The authors' abstract, as published at the source. Chemistry of Materials, 2013 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry