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Chemical Reviews· 2013Q1· Review

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

Thirumurugan Prakasam, Dariusz Matosiuk, Krzysztof Jóźwiak

Short summary

This review details the application of click chemistry, a modular and efficient synthetic strategy, in drug development and various chemical-biology fields.

AI-generated from the title and abstract; the full text is not read.

Key points

  • Click chemistry offers a modular and efficient approach to synthesizing complex molecules.
  • Its high reliability and selectivity are crucial for drug discovery and development.
  • Applications extend beyond pharmaceuticals to bioconjugation, materials science, and diagnostics.
  • The review provides a comprehensive overview of these diverse chemical-biology applications.

AI-generated from the title and abstract; the full text is not read.

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTClick Chemistry for Drug Development and Diverse Chemical–Biology ApplicationsPrakasam Thirumurugan†, Dariusz Matosiuk‡, and Krzysztof Jozwiak*†View Author Information† †Laboratory of Medical Chemistry and Neuroengineering, Department of Chemistry, and ‡Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Medical University of Lublin, Lublin 20093, Poland*E-mail: [email protected]Cite this: Chem. Rev. 2013, 113, 7, 4905–4979Publication Date (Web):March 27, 2013Publication History Received25 October 2011Published online27 March 2013Published inissue 10 July 2013https://pubs.acs.org/doi/10.1021/cr200409fhttps://doi.org/10.1021/cr200409freview-articleACS PublicationsCopyright © 2013 American Chemical SocietyRequest reuse permissionsArticle Views40218Altmetric-Citations1527LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical synthesis,Inhibitors,Monomers,Peptides and proteins,Receptors Get e-Alerts

The authors' abstract, as published at the source. Chemical Reviews, 2013 · DOI ↗

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Field: Organic Chemistry

Organic ChemistryChemistry