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Journal of Medicinal Chemistry· 2015Q1

A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

Brett R. Beno, Kap‐Sun Yeung, Michael D. Bartberger, Lewis D. Pennington et al.

Short summary

Electron-deficient sulfur atoms, with positive electrostatic potential, can interact with oxygen, nitrogen, and pi-systems, influencing molecular conformation and offering underappreciated applications in drug design.

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Field: Physical and Theoretical Chemistry

Physical and Theoretical ChemistryChemistry