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Nature Cell Biology· 2026Q1

Batten disease protein CLN8 enables a non-canonical phospholipid synthesis pathway

Johannes Breithofer, Nermeen Fawzy, Clara Zitta, Martin Tischitz et al.

Short summary

The Batten disease protein CLN8 enables a non-canonical pathway for synthesizing phospholipids, starting with glycerophosphoglycerol and producing lysophosphatidylglycerol, which is then converted to bis(monoacylglycero)phosphate (BMP).

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Field: Physiology

PhysiologyMedicine