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Pharmaceutics· 2026Q1· Review

Chronic Spontaneous Urticaria in the Era of Targeted Therapy: From Pathogenic Mechanisms to Precision Medicine

Klara Andrzejczak, W. Witkowski, Joanna Górka-Dynysiewicz, Robert Pawłowicz et al.

Short summary

Emerging targeted therapies like anti-IL-4Rα, BTK inhibitors (remibrutinib), and anti-c-KIT antibodies (barzolvolimab, briquilimab) show promise for chronic spontaneous urticaria (CSU), with some demonstrating rapid action, though endotype-specific efficacy and predictive biomarkers for treatment selection are still under investigation.

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Field: Rheumatology

RheumatologyMedicine