Cells· 2026Q1
Integrated Single-Nucleus and Epigenomic Profiling Reveals Coordinated Neuro-Glial and Chromatin Remodeling in the Type 2 Diabetic Hypothalamus
- 0citations
- Q1SCImago
- 2026year
Short summary
Type 2 diabetes (T2D) remodels the hypothalamus by altering specific neuronal populations (e.g., Gal.Nts.Npy, Nxph4.Adcyap1, Lmx1a.Gpr149.Tcf4 neurons) and oligodendrocyte-lineage cells, with increased Npy expression linked to greater chromatin accessibility at its locus.
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