Current Opinion in Genetics & Development· 2024Q1· Review
Beyond genomic weaving: molecular roles for CTCF outside cohesin loop extrusion
- 17citations
- Q1SCImago
- 2024year
Short summary
CTCF acts independently of cohesin to regulate nucleosome arrangement, chromatin accessibility, DNA replication, DNA repair, and RNA splicing, revealing multifaceted roles beyond its known function in 3D genome organization.
AI-generated from the title and abstract; the full text is not read.
Abstract
CCCTC-binding factor (CTCF) is a key regulator of 3D genome organization and transcriptional activity. Beyond its well-characterized role in facilitating cohesin-mediated loop extrusion, CTCF exhibits several cohesin-independent activities relevant to chromatin structure and various nuclear processes. These functions include patterning of nucleosome arrangement and chromatin accessibility through interactions with ATP-dependent chromatin remodelers. In addition to influencing transcription, DNA replication, and DNA repair in ways that are separable from its role in loop extrusion, CTCF also interacts with RNA and contributes to RNA splicing and condensation of transcriptional activators. Here, we review recent insight into cohesin-independent activities of CTCF, highlighting its multifaceted roles in chromatin biology and transcriptional regulation.
The authors' abstract, as published at the source. Current Opinion in Genetics & Development, 2024 · DOI ↗
The rest is in the Pofolia app
Takeaways, key points and questions to the paper; new summaries every day for your field. Free.
Sign in on the web to openMolecular BiologyBiochemistry, Genetics and Molecular Biology