Nutrients· 2018Q1· Derleme
Polifenollerin İmmünomodülatör ve Anti-inflamatuar Rolü
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols
- 1.689atıf
- Q1SCImago
- 2018yıl
Kısa özet
Polifenoller, NF-κB'yi inaktive ederek ve MAPK, PI3K/Akt, mTORC1 ve JAK/STAT sinyal yollarını modüle ederek birden fazla moleküler yolu hedefleyerek anti-inflamatuar etkiler gösterir.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- Polifenoller, bağışıklık hücresi fonksiyonlarına ve pro-inflamatuar sitokin sentezine müdahale ederek bağışıklığı düzenler.
- NF-κB'yi inaktive eder ve MAPK, PI3K/Akt, mTORC1 ve JAK/STAT sinyal yollarını modüle ederler.
- Polifenoller antioksidan özelliklere sahiptir ve PLA2, COX ve LOX gibi enzimleri inhibe ederek inflamatuar mediatörlerin üretimini azaltır.
- Bu etkiler, diyabet, obezite ve kardiyovasküler hastalıklar gibi kronik inflamatuar hastalıklarda potansiyel sağlık faydalarına katkıda bulunur.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
This review offers a systematic understanding about how polyphenols target multiple inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear understanding of the molecular mechanisms of action of phenolic compounds. Polyphenols regulate immunity by interfering with immune cell regulation, proinflammatory cytokines' synthesis, and gene expression. They inactivate NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and modulate mitogen-activated protein Kinase (MAPk) and arachidonic acids pathways. Polyphenolic compounds inhibit phosphatidylinositide 3-kinases/protein kinase B (PI3K/AkT), inhibitor of kappa kinase/c-Jun amino-terminal kinases (IKK/JNK), mammalian target of rapamycin complex 1 (mTORC1) which is a protein complex that controls protein synthesis, and JAK/STAT. They can suppress toll-like receptor (TLR) and pro-inflammatory genes' expression. Their antioxidant activity and ability to inhibit enzymes involved in the production of eicosanoids contribute as well to their anti-inflammation properties. They inhibit certain enzymes involved in reactive oxygen species ROS production like xanthine oxidase and NADPH oxidase (NOX) while they upregulate other endogenous antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione (GSH) peroxidase (Px). Furthermore, they inhibit phospholipase A2 (PLA2), cyclooxygenase (COX) and lipoxygenase (LOX) leading to a reduction in the production of prostaglandins (PGs) and leukotrienes (LTs) and inflammation antagonism. The effects of these biologically active compounds on the immune system are associated with extended health benefits for different chronic inflammatory diseases. Studies of plant extracts and compounds show that polyphenols can play a beneficial role in the prevention and the progress of chronic diseases related to inflammation such as diabetes, obesity, neurodegeneration, cancers, and cardiovascular diseases, among other conditions.
Yazarların özeti; kaynağından alınmıştır. Nutrients, 2018 · DOI ↗
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