Nutrients· 2021Q1· Review
Polyphenols and Human Health: The Role of Bioavailability
- 869citations
- Q1SCImago
- 2021year
Short summary
Polyphenols, a class of plant compounds with potential health benefits, exhibit low bioavailability due to food matrix interactions, liver metabolism, and gut microbiota activity, yet their metabolites may possess antioxidant and anti-inflammatory properties.
AI-generated from the title and abstract; the full text is not read.
Key points
- Polyphenols are classified into flavonoid (e.g., flavonols, anthocyanins) and non-flavonoid (e.g., phenolic acids, lignans) groups.
- Low polyphenol bioavailability is influenced by food matrix, liver metabolism (phase I and II), and gut microbiota.
- In vivo metabolites of polyphenols may exert antioxidant and anti-inflammatory effects.
- The review discusses in vivo studies on polyphenol bioavailability and their food sources.
AI-generated from the title and abstract; the full text is not read.
Abstract
Polyphenols are a group of phytochemicals with potential health-promoting effects. They are classified as flavonoid (flavonols, flavanols, flavones, flavanones, isoflavones, and anthocyanins) and non-flavonoid molecules (phenolic acids, hydroxycinnamic acids, lignans, stilbenes, and tannins). Although an increasing number of trials have shown a correlation among polyphenol consumption and a reduction in risk factors for chronic diseases, discrepancies in explaining their positive effects have been found in terms of the bioavailability. In fact, polyphenols show a low bioavailability due to several factors: interaction with the food matrix, the metabolic processes mediated by the liver (phase I and II metabolism), intestine and microbiota. On the other hand, the biological activities of phenol compounds may be mediated by their metabolites, which are produced in vivo, and recent studies have confirmed that these molecules may have antioxidant and anti-phlogistic properties. This review discusses the studies performed in vivo, which consider the polyphenol bioavailability and their different food sources. Factors influencing the biological effects of the main classes of polyphenols are also considered.
The authors' abstract, as published at the source. Nutrients, 2021 · DOI ↗
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Field: Biochemistry (Medicine)
BiochemistryMedicine