Key papers in Biochemistry
Pofolia’s corpus holds 81 papers from the Biochemistry subfield (2012–2023). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
Oxidative Medicine and Cellular Longevity · 2014 · Q1 · SJR 1.00 · FWCI 83.20 · 6,176 citations · Open access
This review synthesizes decades of research on lipid peroxidation, focusing on malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) as key signaling molecules with dual roles in cell biology.
Flavonoids: an overview
Journal of Nutritional Science · 2016 · Q2 · FWCI 54.38 · 5,141 citations · Open access
Flavonoids, natural compounds found in plants, are increasingly recognized for their diverse health benefits and applications in nutraceuticals, pharmaceuticals, and cosmetics due to their antioxidant and anti-inflammatory properties.
Chemistry and Biological Activities of Flavonoids: An Overview
The Scientific World JOURNAL · 2013 · Q2 · FWCI 51.09 · 4,884 citations · Open access
Flavonoids, abundant in fruits, vegetables, tea, and wine, exhibit diverse health benefits including antioxidant, anti-inflammatory, and anticancer activities, with their biological effects linked to their structural configuration.
Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects – A review
Journal of Functional Foods · 2015 · Q1 · FWCI 65.25 · 2,933 citations
This review synthesizes the latest research on phenolic and polyphenolic compounds, highlighting their antioxidant properties and potential health benefits from dietary consumption.
Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits
Food & Nutrition Research · 2017 · Q1 · SJR 1.00 · FWCI 57.94 · 2,912 citations · Open access
Anthocyanidins and anthocyanins, water-soluble pigments found in fruits and vegetables, are explored for their dual roles as natural food colorants and potent pharmaceutical ingredients with significant health benefits.
Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases
Antioxidants and Redox Signaling · 2012 · Q1 · SJR 1.00 · FWCI 52.31 · 2,529 citations
Dietary (poly)phenols show promise against chronic diseases, but their actual impact is unclear due to low plasma concentrations (nM range) and extensive gut microbiota metabolism, which alters their form before absorption.
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
JAMA · 2020 · Q1 · SJR 5.00 · FWCI 189.09 · 2,425 citations
Convalescent plasma transfusion improved clinical status in 5 critically ill COVID-19 patients, leading to fever normalization, reduced organ failure scores, and improved oxygenation.
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
Oxidative Medicine and Cellular Longevity · 2016 · Q1 · SJR 1.00 · FWCI 28.73 · 2,052 citations · Open access
Polyphenols show potential as adjuvant therapy for chronic inflammation and related diseases due to their antioxidant activity and ability to inhibit inflammatory signaling pathways activated by oxidative stress.
Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic Stress
Molecules · 2019 · Q1 · FWCI 62.98 · 1,956 citations · Open access
Plants significantly increase polyphenol production, particularly phenolic acids and flavonoids, via the phenylpropanoid pathway when facing abiotic stresses like drought or salinity.
Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review
Marine Drugs · 2014 · Q1 · SJR 1.00 · FWCI 28.94 · 1,944 citations · Open access
This review synthesizes current knowledge on astaxanthin, a potent carotenoid from natural sources, highlighting its diverse biological activities and commercial applications.
Quercetin, Inflammation and Immunity
Nutrients · 2016 · Q1 · SJR 1.00 · FWCI 29.02 · 1,940 citations · Open access
Quercetin, a plant-derived polyphenol, demonstrates broad anti-inflammatory and immune-modulating effects in vitro and animal models, suggesting potential therapeutic benefits.
Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview
Medicines · 2018 · FWCI 53.20 · 1,937 citations · Open access
This review highlights flavonoids and phenolic compounds from medicinal plants as promising sources for pharmaceutical and medical applications due to their diverse bioactive properties.
Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts
Plants · 2017 · Q1 · FWCI 40.45 · 1,898 citations · Open access
This review highlights the extraction, isolation, and identification of bioactive phenolic compounds from fruits and vegetables as natural alternatives to synthetic food antioxidants like BHT and BHA.
Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica
Journal of Food and Drug Analysis · 2013 · Q2 · FWCI 7.32 · 1,871 citations
100% ethanol effectively extracted the highest antioxidant, phenolic, and flavonoid content from Limnophila aromatica, demonstrating its potential as a dietary source for reducing oxidative stress.
Lipid peroxidation in cell death
Biochemical and Biophysical Research Communications · 2017 · Q2 · FWCI 47.13 · 1,820 citations
Lipid hydroperoxides, arising from excessive oxidation of cell membrane lipids, are increasingly recognized as critical mediators of cell death and disease, altering membrane integrity and modifying cellular components.
FLAVONOIDS: Chemistry, Biochemistry and Applications
2018 · FWCI 18.63 · 1,730 citations
This review synthesizes current knowledge on flavonoids, covering their chemistry, biosynthesis, presence in foods and wine, and diverse biological functions and interactions.
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols
Nutrients · 2018 · Q1 · SJR 1.00 · FWCI 47.63 · 1,689 citations · Open access
Polyphenols exert anti-inflammatory effects by targeting multiple molecular pathways, including the inactivation of NF-κB and modulation of MAPK, PI3K/Akt, mTORC1, and JAK/STAT signaling.
Phenolic acids: Natural versatile molecules with promising therapeutic applications
Biotechnology Reports · 2019 · Q1 · SJR 1.00 · FWCI 48.65 · 1,671 citations
Phenolic acids, naturally occurring molecules, show significant potential for drug discovery due to their versatile therapeutic applications.
Overviews of biological importance of quercetin: A bioactive flavonoid
Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · 2016 · FWCI 21.99 · 1,604 citations
Quercetin, a potent antioxidant flavonoid found in fruits and vegetables, offers protective abilities against tissue injury and may reduce the risk of cardiovascular diseases, metabolic disorders, and certain cancers.
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
The Lancet · 2017 · FWCI 57.94 · 1,453 citations · Open access
Early administration of tranexamic acid significantly reduced death due to bleeding in women with post-partum haemorrhage by 19% compared to placebo, particularly when given within 3 hours.
Recently added
Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases
Frontiers in Chemistry · 2023 · Q2 · FWCI 85.14 · 928 citations · Open access
This review synthesizes current knowledge on how free radicals and oxidative stress contribute to human diseases, highlighting the role of both natural and synthetic antioxidants in counteracting this damage.
Flavonoids as Potential Anti-Inflammatory Molecules: A Review
Molecules · 2022 · Q1 · FWCI 58.53 · 1,011 citations · Open access
Flavonoids, plant-derived hydroxylated polyphenols, exhibit anti-inflammatory effects by activating antioxidant pathways, inhibiting pro-inflammatory enzymes (like COX-2, LOX, iNOS), and modulating key inflammatory mediators (such as IL-1β, TNF-α, NF-κB).
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action
Frontiers in Pharmacology · 2022 · Q1 · SJR 1.00 · FWCI 61.54 · 1,011 citations · Open access
Dietary polyphenols, found in fruits, vegetables, and beverages, protect against oxidative stress and may prevent chronic diseases like neurodegenerative disorders, CVDs, cancer, and diabetes.
Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects
Molecules · 2021 · Q1 · FWCI 37.18 · 810 citations · Open access
Phenolic compounds can inhibit pro-inflammatory mediators and enzymes, offering therapeutic potential for hypertension, metabolic disorders, neurodegenerative diseases, and inflammatory conditions.
Anthocyanins: Factors Affecting Their Stability and Degradation
Antioxidants · 2021 · Q1 · SJR 1.00 · FWCI 30.30 · 836 citations · Open access
Anthocyanins, natural pigments with health benefits, are highly unstable, with their degradation significantly influenced by pH, light, temperature, co-pigmentation, sulfites, ascorbic acid, oxygen, and enzymes.
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