Biochemistry (Medicine) papers
Pofolia’s corpus holds 109 papers from Biochemistry (Medicine) (2012–2026), each with a short summary. Below, the 20 most-cited, then the most recently added.
At a glance
- Most cited: Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal (2014, 6,176 citations).
- The 20 papers listed have 50,565 citations between them.
- 12 of the 16 with a known journal quartile appeared in a Q1 journal.
- 12 have a free full text (open access).
- Most frequent journals: Nutrients, Oxidative Medicine and Cellular Longevity, Antioxidants and Redox Signaling.
- Published between 2012 and 2020.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”. How to read the signals
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
Oxidative Medicine and Cellular Longevity · 2014 · Q1 · SJR 1.00 · FWCI 83.20 · 6,176 citations · Open access
This review synthesizes decades of research on lipid peroxidation, focusing on malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) as key signaling molecules with dual roles in cell biology.
Flavonoids: an overview
Journal of Nutritional Science · 2016 · Q2 · FWCI 54.38 · 5,141 citations · Open access
Flavonoids, natural compounds found in plants, are increasingly recognized for their diverse health benefits and applications in nutraceuticals, pharmaceuticals, and cosmetics due to their antioxidant and anti-inflammatory properties.
Chemistry and Biological Activities of Flavonoids: An Overview
The Scientific World JOURNAL · 2013 · Q2 · FWCI 51.09 · 4,884 citations · Open access
Flavonoids, abundant in fruits, vegetables, tea, and wine, exhibit diverse health benefits including antioxidant, anti-inflammatory, and anticancer activities, with their biological effects linked to their structural configuration.
Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects – A review
Journal of Functional Foods · 2015 · Q1 · FWCI 65.25 · 2,933 citations
This review synthesizes the latest research on phenolic and polyphenolic compounds, highlighting their antioxidant properties and potential health benefits from dietary consumption.
Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits
Food & Nutrition Research · 2017 · Q1 · SJR 1.00 · FWCI 57.94 · 2,912 citations · Open access
Anthocyanidins and anthocyanins, water-soluble pigments found in fruits and vegetables, are explored for their dual roles as natural food colorants and potent pharmaceutical ingredients with significant health benefits.
Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases
Antioxidants and Redox Signaling · 2012 · Q1 · SJR 1.00 · FWCI 52.31 · 2,529 citations
Dietary (poly)phenols show promise against chronic diseases, but their actual impact is unclear due to low plasma concentrations (nM range) and extensive gut microbiota metabolism, which alters their form before absorption.
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
JAMA · 2020 · Q1 · SJR 5.00 · FWCI 189.09 · 2,425 citations
Convalescent plasma transfusion improved clinical status in 5 critically ill COVID-19 patients, leading to fever normalization, reduced organ failure scores, and improved oxygenation.
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
Oxidative Medicine and Cellular Longevity · 2016 · Q1 · SJR 1.00 · FWCI 28.73 · 2,052 citations · Open access
Polyphenols show potential as adjuvant therapy for chronic inflammation and related diseases due to their antioxidant activity and ability to inhibit inflammatory signaling pathways activated by oxidative stress.
Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic Stress
Molecules · 2019 · Q1 · FWCI 62.98 · 1,956 citations · Open access
Plants significantly increase polyphenol production, particularly phenolic acids and flavonoids, via the phenylpropanoid pathway when facing abiotic stresses like drought or salinity.
Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review
Marine Drugs · 2014 · Q1 · SJR 1.00 · FWCI 28.94 · 1,944 citations · Open access
This review synthesizes current knowledge on astaxanthin, a potent carotenoid from natural sources, highlighting its diverse biological activities and commercial applications.
Quercetin, Inflammation and Immunity
Nutrients · 2016 · Q1 · SJR 1.00 · FWCI 29.02 · 1,940 citations · Open access
Quercetin, a plant-derived polyphenol, demonstrates broad anti-inflammatory and immune-modulating effects in vitro and animal models, suggesting potential therapeutic benefits.
Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview
Medicines · 2018 · FWCI 53.20 · 1,937 citations · Open access
This review highlights flavonoids and phenolic compounds from medicinal plants as promising sources for pharmaceutical and medical applications due to their diverse bioactive properties.
Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts
Plants · 2017 · Q1 · FWCI 40.45 · 1,898 citations · Open access
This review highlights the extraction, isolation, and identification of bioactive phenolic compounds from fruits and vegetables as natural alternatives to synthetic food antioxidants like BHT and BHA.
Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica
Journal of Food and Drug Analysis · 2013 · Q2 · FWCI 7.32 · 1,871 citations
100% ethanol effectively extracted the highest antioxidant, phenolic, and flavonoid content from Limnophila aromatica, demonstrating its potential as a dietary source for reducing oxidative stress.
Lipid peroxidation in cell death
Biochemical and Biophysical Research Communications · 2017 · Q2 · FWCI 47.13 · 1,820 citations
Lipid hydroperoxides, arising from excessive oxidation of cell membrane lipids, are increasingly recognized as critical mediators of cell death and disease, altering membrane integrity and modifying cellular components.
FLAVONOIDS: Chemistry, Biochemistry and Applications
2018 · FWCI 18.63 · 1,730 citations
This review synthesizes current knowledge on flavonoids, covering their chemistry, biosynthesis, presence in foods and wine, and diverse biological functions and interactions.
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols
Nutrients · 2018 · Q1 · SJR 1.00 · FWCI 47.63 · 1,689 citations · Open access
Polyphenols exert anti-inflammatory effects by targeting multiple molecular pathways, including the inactivation of NF-κB and modulation of MAPK, PI3K/Akt, mTORC1, and JAK/STAT signaling.
Phenolic acids: Natural versatile molecules with promising therapeutic applications
Biotechnology Reports · 2019 · Q1 · SJR 1.00 · FWCI 48.65 · 1,671 citations
Phenolic acids, naturally occurring molecules, show significant potential for drug discovery due to their versatile therapeutic applications.
Overviews of biological importance of quercetin: A bioactive flavonoid
Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · 2016 · FWCI 21.99 · 1,604 citations
Quercetin, a potent antioxidant flavonoid found in fruits and vegetables, offers protective abilities against tissue injury and may reduce the risk of cardiovascular diseases, metabolic disorders, and certain cancers.
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
The Lancet · 2017 · FWCI 57.94 · 1,453 citations · Open access
Early administration of tranexamic acid significantly reduced death due to bleeding in women with post-partum haemorrhage by 19% compared to placebo, particularly when given within 3 hours.
Recently added
Effects of processing treatments on phenolic content, antioxidant capacity, and anthocyanin levels and antimicrobial activity in fruit pomace fractions
CyTA - Journal of Food · 2026 · Q2
Acidic processing (pH 3.0-3.5) of fruit pomace liquid fractions significantly increases total phenolic content, antioxidant capacity, and anthocyanin levels, with minimal benefit from enzyme addition.
Species-Dependent Citrus–Simvastatin Interaction Profiles in an Acute Rat Model: Integrating Drug Disposition, Hepatic Redox, and Complementary Computational Analysis
Journal of Agricultural and Food Chemistry · 2026 · Q1 · SJR 1.00
Citrus depressa Hayata peel extract, rich in polymethoxyflavones, raised hepatic GSH/GSSG ratio by 227% in rats, uncoupling drug disposition from redox response, unlike grapefruit which primarily disrupted CYP3A and transporter pathways.
Tranexamic acid in proximal femoral megaprosthetic reconstruction for metastatic bone disease
Medicine · 2026 · Q2
Tranexamic acid (TXA) numerically reduced perioperative transfusion needs by 22.4% in patients undergoing proximal femoral megaprosthetic reconstruction for metastatic bone disease (15 TXA vs. 17 control patients), though this difference was not statistically significant.
Lycopene: a review of functional properties, extraction and application in meat field
Critical Reviews in Food Science and Nutrition · 2026 · Q1 · SJR 2.00
This review synthesizes lycopene's health benefits, advanced extraction technologies (ultrasound, microwave, pulsed electric fields), and its application in improving meat product quality, establishing a framework for industrial use.
A comprehensive in vivo and in silico evaluation of the modulatory effects of a lutein and zeaxanthin antioxidant combination on systemic changes induced by diethylnitrosamine in Drosophila melanogaster
BMC Pharmacology and Toxicology · 2026 · Q2
A combination of lutein and zeaxanthin (L/Z) significantly improved survival, restored enzyme activity, and reduced oxidative stress markers in Drosophila melanogaster exposed to diethylnitrosamine (DEN), a common toxin.
Topical Tranexamic Acid in Breast Surgery: A Systematic Review and Meta‐Analysis of Postoperative Bleeding Outcomes
ANZ Journal of Surgery · 2026 · Q2
Topical tranexamic acid (TXA) significantly reduced postoperative drain output by an average of 16.22 mL and lowered the risk of hematoma by 75% in breast surgery patients compared to controls.
Dietary (Poly)phenol Intake, Inflammatory Biomarkers, and Mild Cognitive Impairment in Italian Adults
Antioxidants · 2026 · Q1 · SJR 1.00
Higher habitual intake of total dietary polyphenols, especially flavonoids and lignans, was associated with substantially lower odds of mild cognitive impairment (MCI) in Italian adults aged ≥65 years (highest vs. lowest quartile adjusted OR = 0.08).
Transfusion practices in intensive care units: a Hungarian nationwide survey
Scientific Reports · 2026 · Q1
A nationwide survey of 97 Hungarian ICU physicians reveals that 93.8% use physiological parameters (e.g., ScvO2, lactate, hypotension) for red blood cell transfusion decisions, moving beyond solely hemoglobin levels.
Journals in this field
The journals that publish most of this field’s papers. Quartile (Q1–Q4), SJR and h-index are from SCImago Journal Rank; “in this field” is how many of the journal’s pooled papers belong here. What is a Q1 journal? · What is the h-index?
| Journal | Quartile | SJR | h-index | In this field | Summaries |
|---|---|---|---|---|---|
| Molecules | Q1 | — | 296 | 10 | 33 |
| Nutrients | Q1 | 1.00 | 279 | 8 | 25 |
| New England Journal of Medicine | Q1 | 18.00 | 1275 | 3 | 376 |
| JAMA | Q1 | 5.00 | 818 | 3 | 114 |
| International Journal of Molecular Sciences | Q1 | 1.00 | 365 | 3 | 45 |
| Oxidative Medicine and Cellular Longevity | Q1 | 1.00 | 188 | 3 | 6 |
| Antioxidants | Q1 | 1.00 | 169 | 3 | 8 |
| Annals of Internal Medicine | Q1 | 2.00 | 457 | 2 | 24 |
Every journal in Biochemistry (Medicine) (Q1–Q4) →
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