BioMed Research International· 2015Q2
Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties
- 768citations
- Q2SCImago
- 2015year
Short summary
Dietary polyphenols, after gut microbiota metabolism transforms them into aglycons and other derivatives, exhibit strong antiviral, antibacterial, and antiparasitic activities.
AI-generated from the title and abstract; the full text is not read.
Key points
- Dietary polyphenols are structurally diverse plant compounds, often found as glycosides.
- Gut microbiota metabolism is crucial for transforming polyphenols into bioactive aglycons and derivatives.
- These transformed polyphenols exhibit broad-spectrum antimicrobial properties (antiviral, antibacterial, antiparasitic).
- Polyphenol structure recognition by microbial enzymes is key to their bioactivity.
AI-generated from the title and abstract; the full text is not read.
Abstract
Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become bioactive at human body, these polyphenols must undergo diverse intestinal transformations, due to the action of digestive enzymes, but also by the action of microbiota metabolism. After elimination of sugar tailoring (generating the corresponding aglycons) and diverse hydroxyl moieties, as well as further backbone reorganizations, the final absorbed compounds enter the portal vein circulation towards liver (where other enzymatic transformations take place) and from there to other organs, including behind the digestive tract or via blood towards urine excretion. During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities. This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.
The authors' abstract, as published at the source. BioMed Research International, 2015 · DOI ↗
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Field: Biochemistry (Medicine)
BiochemistryMedicine