Oxidative Medicine and Cellular Longevity· 2016Q1· Review
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
- 2,052citations
- Q1SCImago
- 2016year
Short summary
Polyphenols show potential as adjuvant therapy for chronic inflammation and related diseases due to their antioxidant activity and ability to inhibit inflammatory signaling pathways activated by oxidative stress.
AI-generated from the title and abstract; the full text is not read.
Key points
- Oxidative stress leads to chronic inflammation, a root cause of many chronic diseases.
- Polyphenols exhibit antioxidant activity, counteracting reactive oxygen species (ROS).
- Polyphenols can inhibit enzymes and molecular signaling pathways that drive inflammation.
- These properties suggest polyphenols could be useful in adjuvant therapy for inflammation-mediated disorders.
AI-generated from the title and abstract; the full text is not read.
Abstract
Oxidative stress is viewed as an imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms, which can lead to chronic inflammation. Oxidative stress can activate a variety of transcription factors, which lead to the differential expression of some genes involved in inflammatory pathways. The inflammation triggered by oxidative stress is the cause of many chronic diseases. Polyphenols have been proposed to be useful as adjuvant therapy for their potential anti-inflammatory effect, associated with antioxidant activity, and inhibition of enzymes involved in the production of eicosanoids. This review aims at exploring the properties of polyphenols in anti-inflammation and oxidation and the mechanisms of polyphenols inhibiting molecular signaling pathways which are activated by oxidative stress, as well as the possible roles of polyphenols in inflammation-mediated chronic disorders. Such data can be helpful for the development of future antioxidant therapeutics and new anti-inflammatory drugs.
The authors' abstract, as published at the source. Oxidative Medicine and Cellular Longevity, 2016 · DOI ↗
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Field: Biochemistry (Medicine)
BiochemistryMedicine