Nucleus· 2026Q1
Telomeres in mitosis: organization and dynamics
- 0citations
- Q1SCImago
- 2026year
Short summary
Telomeres, the protective caps on chromosome ends, actively participate in and are organized by key events during mammalian cell division (mitosis), including chromatin condensation and nuclear reassembly.
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Key points
- Telomeres are specialized structures protecting chromosome ends, composed of DNA repeats, shelterin, and accessory factors.
- Telomeric proteins like TRF1 interact with centrosomes and spindle components during mitosis.
- Telomeres interface with chromatin and nuclear membrane reassembly factors (BAF1, LAP2α, ESCRT) during late mitosis.
- Proper telomere dynamics during mitosis are essential for preventing genomic instability and are linked to aging and disease.
AI-generated from the title and abstract; the full text is not read.
Abstract
Telomeres are specialized chromosomal structures that protect chromosome ends and maintain genome stability. Their organization depends on telomeric DNA repeats, the shelterin complex, accessory factors, and telomerase. While telomere structure and maintenance have been characterized, their dynamics during mammalian mitosis remain incompletely understood. Mitosis involves profound cellular reorganization, including chromatin condensation, spindle formation, and nuclear membrane disassembly and reassembly. Emerging evidence suggests that telomeres participate in these processes and may contribute to proper chromosome segregation and post-mitotic chromatin organization. Studies indicate that telomeric proteins such as TRF1 and TNKS1 interact with centrosomes and spindle components, while telomeres also interface with chromatin and nuclear membrane reassembly factors, including BAF1, LAP2α, and the ESCRT machinery during late mitosis. Defects in these processes or interactions can lead to telomere dysfunction and genomic instability. Understanding telomere dynamics during mitosis is therefore critical for elucidating mechanisms underlying aging, laminopathies, and other telomere-related human diseases.
The authors' abstract, as published at the source. Nucleus, 2026 · DOI ↗
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Field: Physiology
PhysiologyMedicine