Journal of Innate Immunity· 2013Q1· Review
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
- 3,551citations
- Q1SCImago
- 2013year
Short summary
Autophagy, a conserved cellular degradation process, acts as an essential antimicrobial defense mechanism against bacteria and viruses in Drosophila, mirroring its role in mammals.
AI-generated from the title and abstract; the full text is not read.
Key points
- Autophagy is a conserved cellular pathway crucial for immunity and host defense.
- Autophagy genes are implicated in restricting diverse pathogens, including bacteria, viruses, and protozoans.
- Studies in Drosophila show autophagy is essential for antimicrobial responses against bacteria and viruses in vivo.
- Antimicrobial autophagy in flies shows striking conservation with mammals, particularly in pathogen-associated pattern recognition triggering the response.
AI-generated from the title and abstract; the full text is not read.
Abstract
Autophagy is a highly conserved degradative pathway that has rapidly emerged as a critical component of immunity and host defense. Studies have implicated autophagy genes in restricting the replication of a diverse array of pathogens, including bacteria, viruses and protozoans. However, in most cases, the in vivo role of antimicrobial autophagy against pathogens has been undefined. Drosophila provides a genetically tractable model system that can be easily adapted to study autophagy in innate immunity, and recent studies in flies have demonstrated that autophagy is an essential antimicrobial response against bacteria and viruses in vivo. These findings reveal striking conservation of antimicrobial autophagy between flies and mammals, and in particular, the role of pathogen-associated pattern recognition in triggering this response. This review discusses our current understanding of antimicrobial autophagy in Drosophila and its potential relevance to human immunity.
The authors' abstract, as published at the source. Journal of Innate Immunity, 2013 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Epidemiology
EpidemiologyMedicine