Journal of Innate Immunity· 2013Q1· Review
Autophagy and Viruses: Adversaries or Allies?
- 4,438citations
- Q1SCImago
- 2013year
Short summary
Autophagy proteins can act as antiviral factors, either through canonical degradation of pathogens or independently of the main pathway, but viruses have evolved to evade and manipulate autophagy for their own survival.
AI-generated from the title and abstract; the full text is not read.
Key points
- Autophagy is a host defense mechanism against viruses, involving pathogen degradation and immune signaling.
- Autophagy proteins can function as antiviral factors independently of the canonical autophagy pathway.
- Viruses have evolved mechanisms to evade autophagic attack.
- Viruses can manipulate the autophagy machinery to promote their own survival and replication.
AI-generated from the title and abstract; the full text is not read.
Abstract
The autophagy pathway is an essential component of host defense against viral infection, orchestrating pathogen degradation (xenophagy), innate immune signaling, and certain aspects of adaptive immunity. Single autophagy proteins or cassettes of the core autophagy machinery can also function as antiviral factors independently of the canonical autophagy pathway. Moreover, to survive and propagate within the host, viruses have evolved a variety of strategies to evade autophagic attack and manipulate the autophagy machinery for their own benefit. This review summarizes recent advances in understanding the antiviral and proviral roles of autophagy and previously unappreciated autophagy-independent functions of autophagy-related genes.
The authors' abstract, as published at the source. Journal of Innate Immunity, 2013 · DOI ↗
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Field: Epidemiology
EpidemiologyMedicine