The Journal of Organic Chemistry· 2026Q2
Asymmetric Copper-Catalyzed Propargylation of 5-Aminopyrazoles with Propargylic Acetates
- 0citations
- Q2SCImago
- 2026year
Short summary
A new asymmetric copper-catalyzed reaction enables the propargylation of 5-aminopyrazoles using propargylic acetates, yielding chiral products with up to 99:1 enantiomeric ratio (er).
AI-generated from the title and abstract; the full text is not read.
Key points
- Developed an asymmetric copper-catalyzed propargylation of 5-aminopyrazoles with propargylic acetates.
- Achieved high enantioselectivity, with products reported up to 99:1 er.
- Obtained products in 51–98% yields across a wide range of substrates.
- Demonstrated practicality through gram-scale reactions and synthetic transformations.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract An asymmetric copper-catalyzed propargylic substitution reaction of propargylic acetates with ambident 5-aminopyrazoles was developed. Under optimized conditions, the relevant products with a wide range of substrates and good functional tolerance were obtained in 51–98% yields and up to 99:1 er. A gram-scale reaction and synthetic transformations demonstrated the practicality, delivering chiral γ-aryl-substituted propargylic products with high enantioselectivity.
The authors' abstract, as published at the source. The Journal of Organic Chemistry, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Organic Chemistry
Organic ChemistryChemistry