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New England Journal of Medicine· 2013Q1

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

Thorsten Klampfl, Heinz Gisslinger, Ashot S. Harutyunyan, Harini Nivarthi et al.

Short summary

Researchers identified somatic mutations in the CALR gene in a significant portion of patients with essential thrombocythemia or primary myelofibrosis lacking JAK2 or MPL mutations, revealing a new molecular marker for these blood cancers.

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Field: Genetics

GeneticsMedicine